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Post-doctoral Research Fellow - Behavioural analysis of brain plasticity and degeneration

Birmingham B15 2TT   •  £31,406 to £33,309  •  Contract/Temporary, Full time


School of Biosciences, University of Birmingham, UK
Post-doctoral Research Fellow "Behavioural analysis of brain plasticity and degeneration".
Grade 7 for 60 months, salary range Grade 7 £31,406 to £33,309
Job Reference: 98709

A Post-doctoral Research Fellow is sought to investigate how experience and behaviour modify the brain throughout life, the impact that experience has on brain structure and how behaviour as a source of experience can impact further. We aim to discover and test underlying molecular mechanisms that regulate structural brain plasticity and neurodegeneration, and link molecules to cells, neural circuits, neurites, synapses and behaviour.

This project will use only the fruit-fly Drosophila as a model organism and focuses on behavioural neurogenetics of Drosophila adult flies, using stablished or custom-made set ups, software for the automatic analysis of behaviour, coding in R, MatLab and related. Laser scanning confocal microscopy, optogenetics and neural circuit manipulation and analysis will also be used.

This project is integrated into a larger project involving two other postdocs, within a Wellcome Trust funded research programme led by Professor A Hidalgo into "A molecular switch between structural brain plasticity and neurodegeneration". It builds on our findings on Drosophila neurotrophins and their Toll and Trk-like Kek receptors, to test the hypothesis that a molecular switch can modify the brain from experience-dependent structural plasticity to neurodegeneration. Using the fruit-fly Drosophila as a model organism, we will discover fundamental principles on how the brain works, how it changes throughout life and how to promote brain health. Our discoveries will reveal cellular and molecular mechanisms underpinning adaptation, learning and memory, neurodegeneration and the structural basis of mental health.

Candidates should have a PhD (or close to completion) in a Life Sciences discipline (e.g. Biology, Biochemistry, Genetics, Neuroscience or related) and/or equivalent research experience, are required.

For informal enquiries contact Professor Alicia Hidalgo at a.hidalgo@bham.ac.uk and +00 44 (0)121 414 54 16.

Visit: https://more.bham.ac.uk/hidalgo/

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Related skills: Cell and Molecular Biology, Biochemistry, Life Science, Laboratory, Research

  • Employer: University of Birmingham
  • Contact: Alicia Hidalgo
  • Phone: 0121 414 5416
  • Reference: 98709
  • Updated: 22nd July 2022
  • Expires: 18th September 2022

University of Birmingham

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