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Bioconjugation Scientist

Tyne and Wear   •  Negotiable  •  Permanent, Full time

Bioconjugation Scientist

An outstanding opportunity has arisen for the right candidate to join our client and develop its high value enabling technology, PermaLink. You will contribute to the successful growth and positioning of the company as a thought leader in this technology arena.

Key Responsibilities

  • Reporting to the Principal Scientist
  • To contribute ideas to technology development strategies and maintain a culture of continual improvement and scientific excellence
  • To provide scientific and technical leadership to antibody development projects
  • To perform conjugation of small molecules (e.g. cytotoxic drugs) to antibodies
  • To perform purification of antibody and ADCs by column chromatography (HIC, SEC, membrane ultrafiltration (TFF)).
  • To analyse the conjugates using analytical chromatography techniques (HIC, SEC, IEX), UV-Vis spectrophotometry and LC-MS
  • To perform the interpretation of analytical results
  • To operate process and analytical equipment and ensure its maintenance
  • To present results in written reports and oral presentations at team meetings

Skills, Knowledge & Experience
It is essential that the successful candidate possess:

  • Experience in setting up bioconjugation reactions to generate ADCs or conjugates with fluorescent dyes or PEG moiety
  • Experience in the purification of the conjugates using a variety of techniques (SEC, desalting, HIC chromatography).
  • Working knowledge of appropriate analytical methods e.g. HPLC, UV-vis spectrometry, SDS-PAGE
  • Knowledge of Antibody Drug Conjugates (ADCs) and protein chemistry
  • Experience of working with antibodies

It is desirable that the successful candidate possess:

  • Knowledge of biopharmaceutical manufacturing or products

Personal Attributes
The ideal candidate would:

  • Be forward thinking and adaptable
  • Be technically competent
  • Have excellent attention to detail
  • Have demonstrable decision-making skills
  • Have the ability to analyse, interpret, and report experimental findings
  • Have a high level of IT proficiency
  • Have excellent communication and interpersonal skills

Education and Training
Minimum of a PhD or equivalent in Chemistry/Protein Biochemistry or related science discipline and 2-4 years industrial experience

  • Agency: Cpl Life Sciences
  • Contact: Amanda Dobson
  • Reference: JO-2105-469548
  • Posted: 28th May 2021
  • Expires: 25th June 2021

Cpl Life Sciences

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