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Human Genetics - Principal Scientist - Computational Biology

Germany   •  Negotiable  •  Permanent, Full time

GWAS - Principal Scientist - RNA-seq - Computational Biology
Competitive salary, generous relocation package, great work-life balance!
If you're a Scientist with experience in Bioinformatics (Human Genetics, GWAS, RNA-seq) looking for a new professional challenge with excellent prospects in a big pharma company, then this could be a perfect fit! Our client, one of the top 20 global leading pharmaceuticals, is looking for a Principal Scientist CompBio to work within their Expert Group as part of their Research Department in an idyllic town in South-West Germany.
Your main responsibilities as a Principal Scientist will include:
*Working as an CompBio Expert within the Computational Biology Group together with members of the Therapeutic Area Partner function and members of the Computational Biology Core function.
*Establishing and developing new analysis strategies for RNA-Seq, single cell RNA-Seq and other NGS approaches.
*Overseeing and contributing to the development of automated standard analysis pipelines, automation of interactions between infrastructure components, or requirements analyses for such systems. Contributing to BI's global computational biology infrastructure in collaborations with bioinformaticians and members of IT and external partners in international teams.
*Acting as the key interface to the NGS lab within the Computational Biology group and play a driving role in the definition of experimental design strategies and coordinate the implementation and development of the LIMS. Together with the NGS lab developing outsourcing strategies.
*Carrying out data analyses to generate and test hypotheses in the context of new therapeutic concepts in collaboration with other members of the Computational Biology group or scientists from BI's Therapeutic Areas for Drug Discovery (Cardiometabolic Research, Central Nervous System Research, Inflammation & Respiratory Research, Immune Modulation & Research Beyond Borders). Supporting others and driving projects as the responsible computational biologist.
*Contributing to projects during all phases from experimental design to downstream analysis as the computational biology specialist in interdisciplinary teams.
The ideal Principal Scientist should be/have:
*PhD degree or equivalent qualification in Computational Biology or related fields several years of post-PhD experience.
*Excellent knowledge and a broad spectrum in bioinformatics and computational biology with a focus on topics related to RNA-Seq, single cell RNA-Seq and other NGS applications. (Ideally analyzed from initial QC to downstream a large number of different RNA-Seq projects, and hands-on experience with scRNA-Seq data from multiple platforms. In addition you have a good overview of recent developments in terms of NGS instruments and protocols. Ideally you have collaborated closely with genomics teams and dealt with LIMS as well)
*Your solid background in statistics and experimental design allows you to define the way forward also for complex questions.
*Several years of experience in R/Bioconductor or Python and at least one additional programming language. You have robust coding skills, experience with version control systems (e.g. git) and constantly strive for well documented and reproducible analyses. In addition you are familiar with Linux, local and cloud-based HPC environments and have experience with queuing systems and modern pipelining systems (e.g. CWL, bpipe etc).
*Experience with other type of omics data, network biology or machine learning is an additional asset.
*Previously demonstrated that you can apply your skills to turn large datasets into relevant insight in concrete biological and disease related topics in interdisciplinary collaborations.
*Fluency in English both in writing and in speaking will enable you to act in an international working environment.
*You are characterized by a focused working style, flexibility as well as innovative thinking, and problem solving and analytical skills.
*You are a reliable team player with excellent organization and communication skills, and with a high degree of motivation.
If you're looking to advance your career with a company that offers competitive salary, very generous relocation packages and excellent benefits as well as the opportunity to become a valuable member of a leading pharmaceutical company that puts an emphasis on a great work-life balance, please get in touch with Anna on +44 (0) 121 616 3469 or alauterjung@pararecruit.com
I'd be happy to discuss your situation and this position with you in more detail and look forward to hearing from you.

Keywords: GWAS, Human Genetics, genome wide association*, Scientist, Computational Biology, Bioinformatics, Genetics, Pharma, Pharmaceutical, RNA-seq, scRNA-seq, pipeline, version control, Germany, Deutschland, RNA, microarray, NGS, WGS, WES, Python, R, LIMS, version, git, github, pipelines, variant calling, Systems Biology

Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities.

You MUST be eligible to work in Germany. Learn more

  • Agency: Paramount Recruitment
  • Posted: 30th June 2017
  • Expires: 28th July 2017
  • Reference: AL300617GWAS
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